A New Brain Drug Delivery Strategy: Focused Ultrasound-Enhanced Intranasal Drug Delivery
نویسندگان
چکیده
منابع مشابه
A New Brain Drug Delivery Strategy: Focused Ultrasound-Enhanced Intranasal Drug Delivery
Central nervous system (CNS) diseases are difficult to treat because of the blood-brain barrier (BBB), which prevents most drugs from entering into the brain. Intranasal (i.n.) administration is a promising approach for drug delivery to the brain, bypassing the BBB; however, its application has been restricted to particularly potent substances and it does not offer localized delivery to specifi...
متن کاملAu Nanoparticle Loaded with 6-Thioguanine Anticancer Drug as a New Strategy for Drug Delivery
In this study we suggested a new strategy for drug delivery of 6-thioguanine (6-TG) as a cancer drug by loading of this thiolic drug at a surface of Au nanoparticles. For this goal, we synthesized Au nanoparticle (Au/NPs) by reduction of tetrachloroauric (III) acid solutions by sodium borohydride and characterized Au/NPs by X-ray powder diffraction (XRD), dynamic light scattering (DLS), Ultravi...
متن کاملIntranasal Drug Delivery to Brain: an Overview
As the people have been suffering from many CNS disorders like Multiple sclerosis, Alzheimer’s disease, Parkinson’s disease many drugs have been developed but they failed in showing the concentration required for action. But nose to brain drug delivery the drug directly enter into the brain. The objective of this review is to provide overview of nose on an physiological, anatomical and, barrier...
متن کاملRecent trends in drug delivery systems: intranasal drug delivery.
Nasal route of drug delivery is commonly known for treatment of local ailments like-cold, cough, rhinitis etc. Recently, efforts have been made to deliver various drugs, specially peptides and proteins, through nasal route for systemic use; utilizing the principles and concepts of rate controlled drug delivery and various polymers and absorption promoters. Considering the large number of proble...
متن کاملFocused ultrasound-enhanced intranasal brain delivery of brain-derived neurotrophic factor
The objective of this study was to unveil the potential mechanism of focused ultrasound (FUS)-enhanced intranasal (IN) brain drug delivery and assess its feasibility in the delivery of therapeutic molecules. Delivery outcomes of fluorescently-labeled dextrans to mouse brains by IN administration either before or after FUS sonication were compared to evaluate whether FUS enhances IN delivery by ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS ONE
سال: 2014
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0108880